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For the new study, published in Science Translational Medicine , Martin Berg, a cell biologist at the University of Gothenburgs Sahlgrenska Cancer Center in Sweden, and his colleagues decided to look at melanoma because rates have been increasing and because the cancer is known to be sensitive to the effects of free radicals

reported that downregulated IIS increased tau phosphorylation, promoted GSK activation, and decreased insulin receptor substrate-1 (IRS1), phospho-Akt, drebrin, and postsynaptic density (PSD95) resulting in cognitive impairment in the HFD model [156]

This protocol is available to patients with appropriate lab work on file