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Traditional systemic administration of anti-ferroptotic agents often faces poor ocular bioavailability and non-targeted toxicity

(2022) [59] comparing GLP-1RA plus SGLT2i combination therapy to GLP-1RA and SGLT2i monotherapies among 1,895 patients with T2DM enrolled in 8 RCTs, the addition of a GLP-1RA to SGLT2i treatment showed that drug discontinuation, diarrhea, injection-site-related events, nausea, vomiting and genital infections were more likely to occur in combination therapy

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The landmark 2008 Gastroenterology study by Dalmasso and colleagues demonstrated that KPV is actively transported into intestinal epithelial cells and colonic immune cells via PepT1