tirzepatide vs semaglutide head to head surmount-1 non-diabetic obesity trial For the first time, and were put in Tirzepatide outperforms semaglutide in NEJM

Because of their intermittent stimulation of the GLP-1R, short-acting GLP-1RAs retain their ability to delay gastric emptying leading to lower postprandial glucose excursions compared with the long-acting GLP-1RAs, which are associated with the development of tolerance (tachyphylaxis) to GLP-1s effect on gastric emptying (10)

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Flubendazole, FDA-approved anthelmintic, elicits valid antitumor effects by targeting P53 and promoting ferroptosis in castration-resistant prostate cancer

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We synthesize current mechanistic and clinical observations within a framework of energy flux constriction and substrate proportionality, highlighting metabolic factors that may influence nutritional stability during sustained pharmacological weight reduction