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Rizzo MR, Marfella R, Barbieri M, Boccardi V, Vestini F, Lettieri B, Canonico S, Paolisso G

Afamelanotide has been reviewed as a treatment that increases pain-free light exposure in adults with EPP in authorised settings

The RIA method exploits the binding reaction between an antibody, a type of protein produced by the immune system, and an antigen, a type of protein found on the surface of foreign substances

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Notably, there was a significant upregulation in the mRNA expression of immune-related genes, including TLR1 , TLR2 , TLR3 , TLR4 , TLR5 , TLR7 , TLR15 , MHC I , MHC II , and MyD88 at various time intervals