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Higher levels are associated with: Type 2 diabetes Fatty liver disease Elevated cholesterol High blood pressure Cardiovascular disease Sleep apnoea This is why many doctors now pay close attention to waist circumference, metabolic markers, and body composition rather than focusing only on total body weight

15 Although high doses generally result in greater weight loss, the incremental benefit diminishes beyond 10 mg once weekly

Adv Sci (Weinh) , 9 (29), e2200927

This divergent evidence may be due to the different experimental conditions of the studies

Zydus Group Lifesciences received US FDA approval for Zituvimet XR (sitagliptin + metformin)