Preclinical studies in both small and large animal models have shown that nerve conduit performance can be enhanced through the use of luminal fillers with structures that are aligned along the long axis of the conduit 12,13,14,15,16,17,18 , sustained release of neurotrophic factors 19,20,21,22,23,24,25 , or through the addition of Schwann and/or stem cells 26,27,28,29,30,31
But off-label use of drugs, in which theyre prescribed to treat conditions for which they werent originally designed, has such a long history in the U.S
And theyre also finding that the use of GLP-1s might also reduce inflammation, and thatllobviously could open up, you know, a variety of different treatments for so many different types of diseases
Over the past few years, GLP-1 medications have moved from niche prescriptions to everyday conversation
Water (800 ml) was slowly added to the mixture at 25-30C and stirred for 2 hr at the same temperature