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Long-term use at physiological or modestly supraphysiological doses hasn't raised safety concerns in the existing literature

4) Integrate multi-disciplinary approaches for clinical translation: Combine artificial intelligence (AI)-driven drug discovery (e.g., machine learning models to predict ferroptosis modulator efficacy using multi-omics data) with network pharmacology to identify synergistic drug combinations (e.g., ferroptosis inhibitors + anti-fibrotic agents)

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10.3389/fnagi.2015.00132 [DOI] [PMC free article] [PubMed] [Google Scholar] Huiyong Y., Libin X., Porter N

Trimethylamine-N-Oxide promotes osteoclast differentiation and bone loss via activating ROS-dependent NF-B signaling pathway