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this approach does not allow an estimate of heterogeneity between studies and may represent a limitation to this NMA given that heterogeneity within the data sets of each analysis is inevitable

Notably, symptom improvements in prebiotic-treated males persisted at weeks 2 and 12, contrasting with transient effects in placebo-treated males (Voigt et al., 2025)

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May cause false elevations in urobilinogen tests 4

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