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A: IGF-1 (insulin-like growth factor 1) is the primary downstream marker of GH activity

The Naglu / cells (the line with metabolic disease), compared to cells of the WT line, have a documented lower antioxidant potential and a lower activity of sulfurtransferases enzymes [43]

Some users maintain low-dose protocols long-term for ongoing joint and tissue support

This dual action activates regenerative TGF- signaling while blocking fibrotic TGF-1/Smad2/3 pathways, demonstrating context-dependent regulatory sophistication

This result supports that the treatment solution can reduce sebum production due to the property of L-carnitine