3.1.2 Astrocytes In ischemic stroke, astrocytes exhibit a dynamic and bidirectional response, initially contributing to BBB dysfunction and edema formation through the release of pro-inflammatory factors and activation of matrix metalloproteinases (MMPs), and later shifting to a neuroprotective phenotype by clearing glutamate, promoting BBB repair, and secreting neurotrophic factors to support tissue recovery (47, 48)
The American Journal of Psychiatry
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Recent studies revealed that Wilms tumor gene on the X chromosome (WTX) and PALB2, a major BRCA2 binding partner known as FANCN, have been shown to interact with the DC domain of KEAP1, inhibit the ubiquitination of Nrf2 and promote NRF2-dependent transcription ( WTX and PALB2 are both considered as tumor suppressor genes since their mutations are often found in kidney tumor (Wilms tumor) and breast and pancreatic cancers, respectively
Chc nng chnh Trong c th, glutathione thc hin nhiu vai tr, bao gm: (1) trung gian trong qu trnh kh c, gip loi b cc cht c hi
