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Literature suggests antioxidant depletion and altered endogenous antioxidant systems precedes OS [12, 13]

39,40 Given the importance of serum phosphate levels, members of the Acute Liver Failure Study Group (commonly referred to as ASFLG) have included serum phosphate levels in their prognostic scoring system for mortality related to APAP hepatotoxicity

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and (ii) induces a quantitative rise of Nrf2 and glutathione that could only be achieved by the highest non-toxic concentrations of the potent experimental Nrf2-activator DEM