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This gradual escalation prevents overwhelming side effects like flushing, nausea, or headaches that occur when starting at high doses, allows the pituitary to adapt to regular stimulation improving long-term response, and provides opportunity to identify minimal effective dose avoiding unnecessary higher dosing and associated costs

Timing Baseline Marker Fasting glucose Why it matters Gives a simple snapshot of current glucose control before interpreting appetite or weight changes

Roberts, M

Practical steps like rotating injection sites, staying hydrated, using gentle skincare products, and following a gradual dose increase schedule can significantly reduce discomfort