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People with uncontrolled high blood pressure, certain heart conditions, glaucoma, hyperthyroidism, or a history of substance misuse may need a different option

In the pathological study of OA, apoptosis has been observed since early times and today chondrocyte apoptosis has been suggested to be an important factor in the pathogenesis of OA (141)

doi:10.1016/j.clim.2020.108544 122 Schloss, J., Leach, M., Brown, D., Hannan, N., Kendall-Reed, P

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It could explain why COVID-19 in these people has a more severe course, with higher vulnerability to cytokine storms and fulminant multi-organ failure