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The 50% rule suggests that medication like GLP-1s can do half the work, but the rest depends on lifestyle changes

Studies suggest that it may achieve this by downregulating pro-inflammatory cytokines like tumor necrosis factor-alpha (TNF-) and interleukin-6 (IL-6) while upregulating anti-inflammatory mediators like interleukin-10 (IL-10)

These are meaningful findings on a compound that has attracted genuine scientific attention

However, clinicians should remain cautious and consider individual health profiles when recommending prolonged therapy

This dual action is thought to contribute to Mounjaro's slightly greater average weight loss in clinical trials