In a primary culture of orbital fibroblasts from GO patients and control subjects treated with H 2 O 2 to induce OS, the antioxidants vitamin C, N-acetyl-L-cysteine, melatonin, retinol, -carotene and vitamin E were found to reduce the manifestations OS (proliferation of fibroblasts, the level of hyaluronic acid, the level of tumor necrosis factor- (TNF-), IFN- and IL1-, which provided the basis for the possible clinical use of these substances in patients with GO (87)
Afterwards, the medium was replaced with fresh DMEM, and the cells were incubated for an additional 48 h
It effectively counteracts the damage induced by stress, cysteamine, and ethanol in experimental models, outperforming several standard treatments
Either an excess or a deficiency of dietary thiols has effects on redox states that are disadvantageous for C
What is most important is the dose