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While SGLT2-i and GLP-1RA may offer additive or synergistic benefits in reducing BP and cardiovascular risk, current guidelines do not support their role as first-line antihypertensive agents or early adjunctive therapies over established agents such as thiazide diuretics, renin-angiotensin system (RAS) inhibitors, or calcium channel blockers (CCBs)

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Still, GLP-1 medications may have benefits far beyond weight loss for heart and liver health, for example which may extend even to people who dont lose as many pounds as they might have expected, experts say

[3] [5] All are available as oral tablets and are generally taken once or twice daily, depending on the specific agent

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