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Clinically, this potent effect is demonstrated by agents like semaglutide, which, in phase 2 trials, achieved MASH resolution without worsening fibrosis in a significant percentage of patients (Newsome et al., 2021

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135 Similarly, a trial in 63 healthy adults with self-reported sleep problems found 14 mg saffron extract twice daily for 28 days led to greater improvement in sleep quality scores than placebo