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These were mostly casecontrol studies evaluating DNA polymorphisms, including one ancestry analysis, as well as expression levels measured as RNA, serum levels of proteins and vitamins, and other potential biomarkers

Participants were mostly white female adults (mean age 4549 years), with a mean BMI of 37.539.3 kg/m 2 10

Interestingly, the neural crest lineage arises from the pluripotent epiblast prior to definitive germ layer formation 44,45

Wilmer MJ, Emma F, Levtchenko EN (2010) The pathogenesis of cystinosis: mechanisms beyond cystine accumulation