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Considering their low MW and non-covalent nature of inhibition of TGR, these compounds were deemed appropriate for fragment-based design

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Studies suggest that body dissatisfaction is at its lifetime high for women during perimenopause, which is alarming given all the other struggles midlife women face

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9 kg), reduces depression scores and improves QoL dimensions such as mood and self-image, with changes correlating with the magnitude of weight loss (138)