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has no conflicts directly related to manuscript, but unrelated to the manuscript serves as consultant for Cove, ExgenesisBio, Exonate, Ltd, Genentech, Neuvasq, Merck & Co Inc, and Perfuse

Network modeling Graph neural networks and other advanced computational tools now enable simulations wherein perturbation of a single node, for example, HSP90 inhibition, can be computationally modeled to predict downstream shifts in UPS engagement or autophagy induction

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