Tirzepatide SURMOUNT-1 (2022) and SURPASS-2 (2021) SURMOUNT-1 (Jastreboff et al., NEJM 2022): 2,539 non-diabetic adults with BMI 30, 72 weeks of tirzepatide 15 mg/week: Weight loss: 20.9% (vs 3.1% placebo) 91% of participants 5% loss, 56.7% 20% SURPASS-2 (Fras et al., NEJM 2021): 1,879 T2D patients head-to-head vs semaglutide 1 mg: HbA1c: 2.30% (tirzepatide 15 mg) vs 1.86% (semaglutide) Weight loss: 11.2 kg vs 5.7 kg Tirzepatide statistically outperforms semaglutide on both HbA1c and weight in a head-to-head trial a rare outcome in incretin pharmacology
But Tuttle stressed that the dip is not an adverse effect its actually a marker that the drug is doing its job
Semaglutide is a potent medication At Curatemd Skin Bar and Wellness Clinic, we offer Semaglutide as part of our Weight loss program, which is tailored to each individuals needs and includes regular check-ins with a healthcare provider to monitor progress and adjust the program as needed
For instance, if a drug is only available as a pill but an elderly patient can't swallow one, a doctor could write a prescription so that a compounding pharmacist could prepare it in liquid form
This alternative still contains the active ingredient semaglutide but it is compounded by a licensed pharmacy