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The semaglutide-to-tirzepatide conversion chart provides dosing equivalencies for a smooth transition

Biochemical measurements Peptide hormones were measured using in-house radioimmunoassays: total GLP-1 (the sum of 7-36NH 2 , 9-36NH 2 and potential mid-terminal cleaved fragments) was measured using a C-terminal specific antibody targeting amidated forms of GLP-1 (code no

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The specific antisense sequences were 5-GGCUCCUACACUUCUGUUATT-3 for FoxO4 siRNA and 5-UAACAGAAGUGUAGGAGCCTT-3 for the negative control