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The observation that patients with AD carrying two alleles of the APOE4 risk variant have approximately half the cerebrospinal fluid (CSF) melatonin levels compared to those with only one allele of this variant [75] could suggests that APOE4/4 carriers might particularly benefit from supplementing with exogenous melatonin
Abbreviations DM: Diabetes mellitus HF: Heart failure EF: Ejection fraction HFrEF: Heart failure with reduced ejection fraction HFpEF: Heart failure with preserved ejection fraction HFmrEF: Heart failure with mildly reduced ejection fraction HFnEF: Heart failure with normal ejection fraction SGLT2i: Sodium glucose cotransporter 2 inhibitors GLP-1 RA: Glucagon-like peptide-1 receptor agonists DPP4i: Dipeptidyl peptidase 4 inhibitors LV: Left ventricular ANP: Abnormal natriuretic peptide EAT: Epicardial adipose tissue AGE: Advanced glycation end LVEF: Left ventricular ejection fraction HHF: Heart failure hospitalization CVD: Cardiovascular death NT-proBNP: N-terminal B-type ANP CIMT: Carotid intima-media thickness TNF-: Tumor necrosis factor- AMPK: Adenosine monophosphate kinase NLRP3: NOD-like receptor 3 ROCK: Rho-associated protein kinase PPAR: Peroxisome proliferator activated receptors References Gregory GA, et al
The findings highlight how cancer cells adapt to survive in nutrient-poor environments
Molecules , 24 (10), 19061909
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