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Retatrutide an investigational triple agonist targeting GLP-1, GIP, and glucagon receptors simultaneously represents the cutting edge of obesity biology research as of 2026

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at China Pharmaceutical University and Nanjing First Hospital: oral Dihexa restored spatial learning and memory in the APP/PS1 transgenic mouse model of Alzheimers disease via the PI3K/AKT signaling pathway, reduced neuroinflammation, and preserved hippocampal synaptophysin expression (Sun et al., Brain Sciences 2021)

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However, it should be noted that GSH at high concentrations (e.g., 30 mM) induces morphological changes in HFF-1 cells (Supplementary Figure S1E)