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About the study Researchers conducted a retrospective cohort study using de-identified electronic health records from the TriNetX United States Collaborative Network between January 2020 and November 2025

Abdominal distension, or swelling Abdominal pain Burping (eructation) Constipation Diarrhea Dizziness Dyspepsia, or upset stomach Fatigue Gas (flatulence) Gastroenteritis Gastroesophageal reflux disease (GERD) Hair loss Headache Heartburn Hypoglycemia Nausea Vomiting These side effects may appear mild at first, but they can escalate in severity or because of symptoms of more serious side effects

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Why this approval matters While the oral version of Wegovy is new, its not the first oral GLP-1 medication to be approved in the U.S