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The nasal bioavailability for small peptides like melanotan is estimated at 10-30% lower than subcutaneous injection (65-95%) but sufficient for meaningful melanocortin receptor activation at appropriate spray doses

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Consistent with our previous results (Jing et al., 2022), lenvatinib significantly reduced L-carnitine content (Figure 2) and downregulated the expression of carnitine-related (Figure 3A) and OXPHOS proteins (Figure 3B) in the skeletal muscle on day 15 of treatment initiation