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Ming X, Johnson WG, Stenroos S, Mars A, Lambert GH, Buyske S: Genetic variant of glutathione peroxidase 1 in autism

Similarly, WT islets treated with GCGR-KO mouse serum exhibited higher VGF expression levels (Fig

doi: 10.1038/s41586-020-2277-x 124 XiaXWLiLJChenZCQiuYZhaoJSWuJYet al

First, while the rescue experiments with ferric citrate and NAC strongly support an iron deficiency and ROS-mediated mechanism, the absence of established positive controls, such as the iron chelator deferoxamine (DFO) or direct ROS generators, precludes a definitive comparative conclusion that the observed effects are uniquely attributable to CGAs iron-chelating activity

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