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Monitoring renal function is key, as dose adjustments may be necessary in patients with impaired kidney function

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The 72-hour minimum rule The prescribing information for tirzepatide (Mounjaro and Zepbound) states clearly: if you want to change the day of the week you take your injection, you must maintain at least 72 hours (three days) between doses

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That said, mood changes can have multiple causes, and stopping GLP-1 therapy comes with its own considerations

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Yes, you can take breaks and restart later

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For semaglutide, official labeling recommends stopping at least two months before a planned pregnancy

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