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Antiproliferative and Proapoptotic Effects of Epigallocatechin Gallate on Human Leiomyoma Cells

Rafeeinia A, Tabandeh A, Khajeniazi S, et al

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The complex's high binding affinity for copper(II) means that GHK can act as a chelator of free copper that might otherwise participate in damaging Fenton-like reactions, sequestering the metal in a form less reactive with cellular targets

In addition, GPx-4 depletion in cell culture also promotes cell death by apoptotic mechanisms that could not be alleviated with water-soluble antioxidants, confirming that intracellularly GPx-4 mainly prevents lipid peroxidation, essentially antagonizing the actions of lipoxygenases and cycloogenase