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Mean body weight changes across the groups at the end of 32 weeks were: CagriSema: 15.6% Semaglutide alone: 5.1% Cagrilinitide alone: 8.1% [43] Side effects included nausea (29% of patients), diarrhea (16%) and vomiting (10%) in CagriSema treated patients

I 2 = 86%) and decreased HbA1c (MD 0.79

Weight loss achieved through GLP-1 drugs can improve blood sugar control, reduce inflammation and enhance insulin sensitivity, factors that may positively influence reproductive function

Tirzepatide targets both GLP-1 and another incretin receptor called GIP

Intrathecal administration of exenatide upregulated IL-10 and -endorphin expression in spinal microglia of neuropathic rats [63]