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I think that jury is still out. Its possible that GLP-1s are affecting the brain and body in ways that researchers dont yet fully understand

Although microbial-based interventions, such as probiotics, demonstrate therapeutic potentialfor instance, certain strains of Lactobacillus and Bifidobacterium have shown preliminary efficacy in alleviating depressive symptoms (281)their benefits in schizophrenia remain inconsistent and lack high-quality clinical support (282)

Maintaining gradual rather than precipitous weight loss, ensuring adequate hydration, and avoiding prolonged fasting may help, but these approaches have not been specifically validated in patients taking these medications

Supplementing with cysteine and glycine for just two weeks restored concentrations to levels comparable to those of younger adults

Adverse gastrointestinal events included pancreatitis, bowel obstruction, and gastroparesis