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Clinical Takeaway If you understand: Hormonal regulation Lipoprotein dynamics Enzyme control points Insulin resistance physiology You understand the foundation of cardiovascular disease

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Potential side effects include local skin irritation, contact dermatitis, and theoretical drug interactions if systemic absorption occurs

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Some of the strongest signals of benefit came from a study of more than 12,000 patients that showed GLP-1 use was associated with markedly lower odds of cancers advancing to metastatic disease, particularly in lung, breast, colorectal and liver cancers