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(IV) The metal nanomedicines show great potential for cancer therapy not only because of the capability of GSH exhaustion, but also for their wide range of other biological effects, such as interference with osmotic pressure, regulation of the immune system, and activation of biocatalysis ( in vivo metabolism and excretion behavior of metal nanomedicines should also be conducted

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It blocks DNA methylation by inhibiting DNA methyltransferase and induces cell cycle arrest in the G2/M phase through the p53-independent pathway in human cancer cells

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