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This group described decreased activity of nicotinamide N-methyltranserase (NNMT), an enzyme that catalyzes the N-methylation of nicotinamide and other pyridines in the CSF of younger PD patients compared with younger controls, and a trend toward decrease with aging in PD patients (Aoyama et al., The results of studies on neurotoxins related with the risk for PD are based on small series and are not conclusive

doi: 10.3389/fgene.2021.783713 270

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Special thanks are also extended to the Comprehensive Research Laboratory and the Center for Breeding and Cultivation of Laboratory Animals at the Jiroft University of Medical Sciences for their invaluable resources and assistance throughout this research

Having evolved beyond its origins as a business model concept, CE is increasingly recognized as a novel urban development paradigm aimed at closing material loops to strengthen local economies and social redistribution (Williams, 2021)