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It also raises the available amount of SAMe (S-adenosylmethionine), the important compound which lifts mood and works as a tricyclic antidepressant

As a result, an accumulation of Lipid-OOH occurs: since GSH is the reducing co-substrate of GPX4, able to regulate the redox state of the cell-forming Lipid-OH (Figure 2A), GSH depletion can negatively regulate GPX4, triggering ferroptosis [19]

For confirmed deficiency or pernicious anaemia, NICE Clinical Knowledge Summaries recommend hydroxocobalamin 1mg intramuscularly, with frequency determined by the underlying cause and neurological involvement

10.1016/j.neuint.2023.105490 Neurochem

ACS Omega 8:2567425697