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[ClinicalTrials.gov] FDA

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Limitations The major limitations of the studies that are included in this systematic review are the enrollment of healthy subjects and insufficient data in conditions that might affect pharmacokinetics (e.g., kidney dysfunction)

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Today, second- and higher-generation ADT drugs are administered, often in combination and earlier in CaP progression and more frequently with other classes of CaP drugs, such as the chemotherapeutic docetaxel [14,15,16,17]