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The increased -MSH activates the melanocortin four receptor (MC4R) (140), which in turn mobilizes the sympathetic nervous system, inhibits insulin secretion, enhances hepatic insulin sensitivity (141), and suppresses appetite by modulating NPY/AgRP neurons that promote insulin (142)

This highlights a critical gap in current research, where a more nuanced approach is necessary to illustrate the circumstances under which NAC exerts beneficial effects

Liu, Z.-W., Ma, Q., Liu, J., Li, J.-W

10.1016/j.bioorg.2017.02.011 20 KharbR.HaiderK.NehaK.YarM

Metere A, Frezzotti F, Graves CE, Vergine M, De Luca A, Pietraforte D, Giacomelli L