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[6] The most frequently reported adverse reactions-paranesthesia of the distal extremities, dysgeusia, somnolence, concentration difficulties, weight loss, and dizziness-occur in up to 40 % of patients during rapid titration but decline substantially with slower dose escalation and hydration

Nevertheless, it is worth mentioning that other compounds, such as Curcumin (Shahcheraghi et al., 2022), Resveratrol (Yadav et al., 2022) or Ursodiol (Huang, 2021) also have been reported to exert activating effects on NRF2 in neurodegenerative diseases

IU = international unit

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