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However, modern research indicates that GCGR agonism increases thermogenesis and energy expenditure through the activation of futile cycles in the liver and potentially the recruitment of brown adipose tissue
Tirzepatide carries a boxed warning for thyroid C-cell tumors and is contraindicated in patients with a personal or family history of medullary thyroid carcinoma (MTC) or Multiple Endocrine Neoplasia syndrome type 2 (MEN2)
Incretin mimetics include medications such as GLP-1 agonists, which mimic these effects
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