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In one double-blind, randomized, placebo-controlled trial in patients with liver disease and thrombocytopenia about to undergo an invasive procedure, pretreatment with 75 mg eltrombopag daily for 2 weeks significantly reduced the need for platelet transfusions (Afdhal 2012)
MK-677 has no such preparation requirement
Mechanism well-characterized in dermal fibroblasts
They follow USP 797 guidelines for sterile compounding, which specify requirements for personnel training, cleanroom environments, and quality control
Tony Urey about the idea that amyloidosis can be a multisystem diseasewhile clinical attention has often centered on cardiac manifestations, particularly in wild-type transthyretin amyloidosis, which has historically been framed primarily as a cardiac condition
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