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Constipation was less common than with some single-target GLP-1 compounds, possibly due to the glucagon component stimulating gut motility

this was demonstrated directly in tendon fibroblast cultures by Chang 2011

PMID 9151953

In 2026, it remains the most evidence-backed carrier peptide in cosmetic science

By identifying the specific region of growth hormone responsible for lipolytic activity (amino acids 176-191) and isolating this fragment, scientists created a targeted intervention with improved safety profile, fewer contraindications, reduced side effects, and simpler monitoring requirements compared to full growth hormone