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They catalyze the decarboxylation of pyruvate, -ketoglutarate, 2-oxoadipate, and branched-chain amino acids (BCAA) to form acetyl-coenzyme A (CoA), succinyl-CoA, glutaryl-CoA, and derivatives of BCAA, respectively ( Figure 1 )
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The immunohistochemical analysis procedure was the same as that used in our previous study (16), in which we examined GLP-1R expression in PNETs and found no significant associations between the receptor expression status and several clinicopathological characteristics
It looks well tolerated in animals
