While some studies suggest a possible correlation between GLP-1 RAs and intestinal obstruction, others report no significant association, with discrepancies likely due to variations in study demographics, methodologies, and GLP-1 RA formulations
Volixibat (VLX) is an ileal bile acid transporter (IBAT) inhibitor that interrupts BA uptake in the small intestine, leading to greater BA fecal elimination with subsequent reductions in the systemic BA pool
In a polymicrobial model of sepsis induced by cecal ligation and puncture, a GLP-1 analog ameliorated vascular inflammation and oxidative stress by improving endothelial function ( In a cardiac fibrosis model, the GLP-1 analogue liraglutide reduced vascular reactivity, cardiac hypertrophy, fibroblast accumulation, collagen deposition and MCP-1 production ( GLP-1 improved left ventricular function in patients with chronic heart failure and in dogs with dilated cardiomyopathy
Gurjar AA, Kushwaha S, Chattopadhyay S, Das N, Pal S, China SP, et al
Nucleic acid molecules comprising nucleotide sequences that encode the human antibodies of the present invention as defined herein or parts or fragments thereof, or nucleic acid molecules substantially homologous thereto, form yet further aspects of the invention