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In addition to increased transcription of NRF2 target genes, livers from Gclc KO mice had lower expression of lipogenic genes and proteins (Fig

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Cochrane Database Syst Rev, 2012 CD006616

4 Pharmacokinetic properties A full understanding of its behavior in biological systems, essential for further caudatin development as a clinical agent, can only be achieved since the pharmacokinetic (PK) profile determines absorption, distribution, metabolism, and elimination (ADME), and parameters that control both safety and efficacy ( Quantitative characterization of the caudatin PK profile has been primarily derived from studies in rats, and particularly those that have successfully quantified using sensitive UPLC-MS/MS technology ( The pharmacokinetic profile of caudatin undergoes substantial modification in pathological states, particularly HCC