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6 Aerobic exercise Regular aerobic activity, such as brisk walking, cycling, or swimming, reduces systolic blood pressure by approximately 4.5 mmHg on average

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Furthermore, melatonin treatment decreased infarct size in isolated hearts with regional ischemia reperfusion by mitigating sarcoplasmic reticulum calcium (2+) [SR-Ca(2+)] homeostasis in cardiomyocytes and reducing the expression of nicotinamide adenine dinucleotide phosphate oxidase (p22 and NOX2) and antioxidant enzymes [catalase (CAT) and manganese-superoxide dismutase (MnSOD)]

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Ther Adv Endocrinol Metab 10:2042018819863226