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Notably, TCM-derived modulators exert synergistic effects by targeting multiple pathological links in RA, including synovial inflammation, fibroblast-like synoviocyte proliferation, immune imbalance, and bone destruction

The methylation pathway involves the SAM-dependent enzyme histamine N -methyltransferase which is encoded by the HNMT gene

Since ROS induce tissue damage, thrombosis and red blood cell dysfunction that contribute to COVID-19 disease severity, administration of free radical scavengers could be beneficial for the most vulnerable patients (Laforge et al., 2020)

Idebenone, a mitochondrial electron transport chain regulator with antioxidant properties, has been used to treat mitochondrial diseases by reducing ROS levels and improving mitochondrial function [521]

Complex cell death signaling networks revealed in erythrocytes have fueled an interest in unveiling the crosstalk between lethal subroutines