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These include systemic medications such as methotrexate, cyclosporine, retinoids, 6-thioguanine, mycophenolate mofetil, troglitazone, and new biologic agents like adalimumab, alefacept, efalizumab, etanercept, and infliximab, as well as topical therapies like steroids, vitamin D analogues, psoralen, 5-aminolevulinic acid, salicylates, fumaric acid esters, anthralins (dithranol), tacrolimus, and retinoids, such as tazarotene

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For example, arterialvenous blood sampling and isotope tracing experiments in pigs indicate that circulating citrate contributes to the tricarboxylic acid (TCA) cycle most prominently in the kidneys and to an extent that is similar to glutamine and lactate 22