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Receptor desensitization is a protective mechanism where cells reduce their responsiveness to a signaling molecule when that molecule is present in excessive amounts

A differenza di altri farmaci, come gli analoghi del GLP-1 o la tirzepatide, che agiscono prevalentemente sui segnali metabolici e ormonali della saziet, il bupropione/naltrexone ha un effetto pi diretto sui circuiti neurobiologici coinvolti nella regolazione del comportamento alimentare

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The capsule format provides a convenient, pre-measured delivery vehicle for oral administration research protocols

According to the SmPC, the most frequently reported adverse effects include nausea (occurring in approximately 44% of patients in clinical trials), vomiting (25%), diarrhoea (30%), constipation (24%), and abdominal pain (27%)