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63 Most of these variants have DNA mutations at exon 10, an area which affects monomer-dimer interactions and thereby enzyme activity

62,98 Clinical Studies in PD In a proof of concept open label clinical trial, 45 patients with moderate PD, on convential PD therapy, were randomly assigned to receive subcutaneous exenatide injection (in the form Byetta : 5 g administered subcutaneously twice daily for the first month followed by a 10 g dose twice daily thereafter) or were controls for 12 mo, followed by a 2-mo washout period to allow comparison between the exenatide and control groups in the absence of drug (to potentially avoid any potential symptomatic effects of exenatide)

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as GLP-1 medications stabilize blood glucose levels and reduce glycemic variability, patients frequently experience resolution of these symptoms and perceive increased vitality

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