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Through the actions of GTP cyclohydrolase 1 GTP is converted to 7,8-dihydroneopterin triphosphate

A distinct nonclassical inflammasome pathway is triggered by direct binding of lipopolysaccharide (LPS) to caspase 11 (CASP11 in humans) or caspase 4/5 (CASP4/5 in mice), resulting in GSDMD cleavage [139]

Finally, considering the potential application of these thioamide-derived warheads in TCIs, we performed in vitro human liver microsome metabolism experiments and assessed the remaining compounds by HPLC measurements (Supplementary Fig

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